COVID Infection Protects Like Two Vaccine Doses: Review of 65 Studies (2/16/2023)
Posted by FactReal on February 28, 2023
A review of 65 studies from 19 countries confirmed COVID natural immunity: Prior COVID infection is at least equivalent if not greater than that provided by two-dose mRNA vaccines.
The review was published by the Lancet Journal on Feb. 16, 2023.
Study Findings: [Emphasis added]
We identified a total of 65 studies from 19 different countries. Our meta-analyses showed that protection from past infection and any symptomatic disease was high for ancestral [original], alpha, beta, and delta variants, but was substantially lower for the omicron BA.1 variant. Pooled effectiveness against re-infection by the omicron BA.1 variant was 45·3% (95% uncertainty interval [UI] 17·3–76·1) and 44·0% (26·5–65·0) against omicron BA.1 symptomatic disease. Mean pooled effectiveness was greater than 78% against severe disease (hospitalisation and death) for all variants, including omicron BA.1. Protection from re-infection from ancestral, alpha, and delta variants declined over time but remained at 78·6% (49·8–93·6) at 40 weeks [10 months]. Protection against re-infection by the omicron BA.1 variant declined more rapidly and was estimated at 36·1% (24·4–51·3) at 40 weeks. On the other hand, protection against severe disease remained high for all variants, with 90·2% (69·7–97·5) for ancestral, alpha, and delta variants, and 88·9% (84·7–90·9) for omicron BA.1 at 40 weeks.
Our findings show that immunity from COVID-19 infection confers substantial protection against infection from pre-omicron variants. By comparison, protection against re-infection from the omicron BA.1 variant was substantially reduced and wanes rapidly over time. Protection against severe disease, although based on scarce data, was maintained at a relatively high level up to 1 year after the initial infection for all variants. Our analysis suggests that the level of protection from past infection by variant and over time is at least equivalent if not greater than that provided by two-dose mRNA vaccines.
Objective of the Study:
“The objective of this study is to systematically synthesise all available studies to estimate protection from past infection by variant, and where data allow, by time since infection.”
About the Study
“We identified 65 studies from 19 different countries (Austria, Belgium, Brazil, Canada, Czechia, Denmark, France, India, Italy, Netherlands, Nicaragua, Norway, Qatar, Scotland, South Africa, Sweden, Switzerland, the UK, and the USA[.]”
COVID Total Deaths & Infections (Worldwide)
“As of June 1, 2022, the COVID-19 pandemic had caused an estimated 17·2 million total deaths (6·88 million reported deaths), and an estimated 7·63 billion total infections and re-infections.”
[Footnote 1 links to a study published in March 2022 explaining the global death toll due to the Chinese Coronavirus: Estimating excess mortality due to the COVID-19 pandemic: a systematic analysis of COVID-19-related mortality, 2020-21:
Although reported COVID-19 deaths between Jan 1, 2020, and Dec 31, 2021, totalled 5·94 million worldwide, we estimate that 18·2 million (95% uncertainty interval 17·1–19·6) people died worldwide because of the COVID-19 pandemic (as measured by excess mortality) over that period.
– “The protection against Covid-19 from being previously infected lasts at least as long as that offered by vaccination, one of the largest studies conducted on the subject said on Friday.”
– “Ten months after getting Covid, people still had an 88 percent lower risk of reinfection, hospitalisation and death, according to the study published in the Lancet journal.”
– “That makes this natural immunity “at least as durable, if not more so” than two doses of Pfizer or Moderna’s vaccines, the study said.”
– “Protection from reinfection was highest for the ancestral (original) strain of COVID-19 and the alpha, beta and delta variants, remaining at more than 78% after 40 weeks.”
– “Protection was lower for the omicron BA.1 variant, which dropped to 36.1% in that same time frame.”
– “When it comes to severe disease (hospitalization or death), protection was high across all variants, averaging 78% or higher for ancestral, alpha, beta, delta and omicron BA.1 at 40 weeks after infection.”
– “The level of protection declined over time for all variants, but it dipped fastest for the omicron BA.1 variant.”
REVIEW FUNDED BY BILL GATES’ FOUNDATION
Funding for the study was provided by:
“Bill & Melinda Gates Foundation, J Stanton, T Gillespie, and J and E Nordstrom.”
Role of the funding source:
“The funders of the study had no role in the study design, data collection, data analysis, data interpretation, or the writing of the report.”
This entry was posted on February 28, 2023 at 7:07 pm and is filed under Healthcare.
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